Kolchin 0.6mg Tablet 10pcs

Uses of Kolchin 0.6mg Tablet

Acute gout, Familial Mediterranean Fever, Behcet's disease, Gouty arthritis

How does Kolchin 0.6mg Tablet work?

It works by inhibiting the migration of natural substances that cause inflammation into the inflamed area.

Side Effects of Kolchin 0.6mg Tablet

• Diarrhea
• Nausea and Vomiting
• Stomach pain
• Headache
• Muscle weakness
• Skin rash
• Hair loss
• Decreased appetite

Quick Suggestions:

• Kolchin 0.6 is used for treating and preventing gout.
• It interacts with many medications. Inform your doctor about all the drugs you are taking.
• Inform your doctor if you experience severe nausea, vomiting, diarrhea, or tingling in fingers or toes.
• It can reduce your body's ability to make new blood cells. Report any frequent bleeding, bruising, fevers, or persistent tiredness to your doctor.
• Avoid Kolchin 0.6 if you have severe liver or kidney disease, or if you are pregnant or breastfeeding.

Indications:

• Acute Gout

Colchicine is used in the treatment of gout which is a type of arthritis characterized by pain and inflammation of joints.

• Familial Mediterranean Fever

Colchicine is used in the treatment of Familial Mediterranean Fever which is an inherited condition characterized by recurrent fevers and painful inflammation of your abdomen, chest, and joints.

Pharmacology

Colchicine reduces inflammation by decreasing the inflammatory response to urate crystals and inhibiting lactic acid production by leukocytes, interrupting urate deposition and the inflammatory response.

Dosage & Administration of Kolchin 0.6mg Tablet

Adult Dose

• Acute gout flares: 1.2 mg initially, then 0.6 mg one hour later; max 1.8 mg in one hour.
• Prophylaxis: 0.6 mg once or twice daily; max 1.2 mg/day; after a flare, wait 12 hours before resuming prophylaxis.
• Familial Mediterranean Fever: 1.2-2.4 mg/day in single or divided doses; increase or decrease by 0.3 mg/day as necessary.

Child Dose

• Gout: Not recommended for under 16 years.
• Familial Mediterranean Fever:
  • 4-6 years: 0.3-1.8 mg/day in single or divided doses.
  • 6-12 years: 0.9-1.8 mg/day in single or divided doses.

12 years: 1.2-2.4 mg/day in single or divided doses.

Renal Dose

Renal impairment

• Mild to moderate: No adjustment needed; monitor for adverse effects.
• Severe: 0.3 mg/day initially; monitor and adjust as necessary.

Interaction

• May cause reversible malabsorption of vitamin B12 and increase response to CNS depressants and sympathomimetics.
• Increased risk of myopathy with simvastatin.
• Potentially fatal interactions with ciclosporin and macrolides, increase the risk of nephrotoxicity and myotoxicity.

Contraindications

Hypersensitivity; blood dyscrasias, severe renal impairment, pregnancy, debilitated patients; SC/IM administration.

Pregnancy & Lactation

• Pregnancy: No drug-associated risks for major birth defects, miscarriage, or adverse outcomes identified from published literature.
• Lactation: Present in human milk with no adverse events reported. Consider the benefits of breastfeeding and the mother's need for the drug.

Precautions & Warnings

• Use with caution in elderly patients and those with GI, cardiac, renal, and hepatic impairment. Prolonged therapy is not recommended.
• The drug enters breast milk; use with caution during lactation.

Storage Conditions:

Protect from light, store below 30°C. Keep the medicine out of the reach of children.